antibody affinity maturation

基本解释

Conclusion Error-prone PCR is an effective and simple method for affinity maturation of antibodies isolated from a phage antibody library.
结论错配PCR结合噬菌体展示技术是提高单链抗体亲和力的一种有效且简便的手段。
Because this method was to simulate the process of antibody maturation in vivo, the obtained antibodies was not only fully humanized but also with relatively high affinity.
该方法体外模拟了抗体亲和力成熟的过程，使得到的抗体不但可以完全的人源化，而且可以具有较高的亲和力。
The algorithm is inspired by the mechanism in which a kind of antibody can identify multi-epitope of an antigen and gradually accomplish affinity maturation in the evolutionary process.
基于免疫细胞中不同亲和度抗体具有不同的变异率，最终通过不断进化达到亲和度成熟机理的启示，设计并实现了一个多模态免疫优化算法。