take issue

基本解释

Let me first clarify that I don't take issue with the trend itself.
让我首先澄清一下，我不打算把这议题当作趋势本身。
Some people take issue, for example, with the methodology based on 13 surveys of experts and business people.
比如，一些人质疑根据专家和商人意见得出13份调查报告的统计方法。
What I feel compelled to take issue with, and the reason I am writing this treatise, is that the actual paradigm of medical care has not changed much in spite of all of our technological advances.
我感觉现在急迫的问题，也是我写下本文的原因，是尽管我们的技术进步很快，但是实际医疗方式却没有太大变化。

They take issue with opponents, some of whom invoke images of Nazi Germany and accuse the Obama administration of wanting to trample the Constitution and individual rights.
There's never been a successful third-party political culture take hold in this country without one really big issue to drive it.
美国就从没有过,第三政党真正成功执政的时候,因为缺乏一个真正重大的议题来支持它
耶鲁公开课 - 美国内战与重建课程节选
What this is, is you take a group of studies on an issue, you pool them all together, and then you weight studies differently depending on factors like how large they were, how good their methods were, and then you come out with overall estimates about the impact of something, in this case the Mediterranean Diet, on health outcomes.
所谓荟萃分析就是将某一问题的一组研究,汇总起来,并根据某些因素,赋予这些研究不同的权重,如基于研究的大小,研究方法的好坏等,然后得出关于某事物的影响的总体评估,在地中海式饮食中就是指健康结果
耶鲁公开课 - 关于食物的心理学、生物学和政治学课程节选

Put another way, to take issue with market returns is like arguing against the speed limit.
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